Human SPINK5 ELISA Kit (Colorimetric)

Key Product Details

Product Specifications

Precision

Intra-Assay Precision (Precision within an assay) %CV 10 (example only; lot dependent)

Inter-Assay Precision (Precision between assays) %CV 12 (example only; lot dependent)

Scientific Data Images for Human SPINK5 ELISA Kit (Colorimetric)

Kit Contents for Human SPINK5 ELISA Kit (Colorimetric)

• Detection Reagent A
• Detection Reagent B
• Diluent Buffer
• Instruction manual
• Plate sealer for 96 wells
• Pre-coated 96T strip plate
• Standard
• Stop Solution
• TMB Substrate
• Wash Buffer (30 x concentrate)

Preparation and Storage

Background: LEKTI/SPINK5

LEKTI, encoded by the SPINK5 gene, is a serine proteinase inhibitor with activity toward Kallikreins, Plasmin, Subtilisin A, Cathepsin G, Elastase, and Trypsin. It is primarily expressed in differentiated keratinocytes and is found in multiple forms due to alternative splicing and proteolytic cleavage. In the skin, LEKTI regulates the ability of KLK5, KLK7, and KLK14 to degrade the desmosomal proteins Desmoglein-1 and Desmoplakin-1 during desquamation. Mutations in SPINK5 and loss of its expression are associated with the development of various skin disorders such as Netherton syndrome, atopic eczema, and atopic dermatitis.

Additional LEKTI/SPINK5 Products

• All Products for LEKTI/SPINK5
• LEKTI/SPINK5 ELISA Kits
• LEKTI/SPINK5 Primary Antibodies
• LEKTI/SPINK5 Proteins and Enzymes

Product Documents for Human SPINK5 ELISA Kit (Colorimetric)