SPOP-i-6lc

Key Product Details

Product Description

SPOP-i-6lc is a selective SPOP E3 ubiquitin ligase inhibitor (IC₅₀ = 2.1 μM and 3.5 μM, in A498 and OS-RC-2 cell lines, respectively). In vitro, SPOP-i-6lc suppresses viability and proliferation of A498 and OS-RC-2 kidney cancer cell lines. SPOP-i-6lc leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma (ccRCC) cell lines.

Product Specifications for SPOP-i-6lc

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SPOP-i-6lc

The following data is based on the product molecular weight 505.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.78 mL	98.88 mL	197.77 mL
0.5 mM	3.96 mL	19.78 mL	39.55 mL
1 mM	1.98 mL	9.89 mL	19.78 mL
5 mM	0.40 mL	1.98 mL	3.96 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dong Structure-activity relationship of SPOP inhibitors against kidney cancer. J.Med.Chem. 2020 PMID: 32297747

Product Documents for SPOP-i-6lc