SPP 86

Catalog # Availability Size / Price Qty
5391/10
5391/50
Additional RTK Inhibitors Small Molecule
1 Image
Description: Potent RET inhibitor

Chemical Name: 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity: ≥98%

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Biological Activity

Potent RET inhibitor (IC50 = 8 nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro. Cell permeable.

Technical Data

M.Wt:
277.32
Formula:
C16H15N5
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1357349-91-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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