Potent RET inhibitor (IC50
= 8 nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro
. Cell permeable.
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All Tocris products are intended for laboratory research use only.
Preparation of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET kinase inhibitors.
Dinér et al.
Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases.
Klein et al.
PLoS ONE, 2011;6:e20789