SPP 86

Catalog # Availability Size / Price Qty
5391/10
5391/50
Cat.No. 5391 - SPP 86 | C16H15N5 | CAS No. 1357349-91-7
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Description: Potent RET inhibitor

Chemical Name: 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Biological Activity

Potent RET inhibitor (IC50 = 8 nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro. Cell permeable.

Technical Data

Formula:
C16H15N5
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
1357349-91-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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