Chemical Name: [[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid tetraethyl ester
Biological ActivitySR 12813 is a pregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μM concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Berkhout et al.
Discovery of a highly active ligand of human pregnane X receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.
Lemaire et al.
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
Jones et al.
Citation for SR 12813
The citations listed below are publications that use Tocris products. Selected citations for SR 12813 include:
1 Citation: Showing 1 - 1
Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.
Authors: Delfosse Et al.
Nat Commun 2015;6:8089
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