Pregnane X receptor (PXR) agonist (EC50
values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ
M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.
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All Tocris products are intended for laboratory research use only.
The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Berkhout et al.
Discovery of a highly active ligand of human pregnane X receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.
Lemaire et al.
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
Jones et al.