SR 12813

Catalog # Availability Size / Price Qty
2969/10
2969/50
SR 12813 | CAS No. 126411-39-0 | Pregnane X Receptor Agonists
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Description: Pregnane X receptor agonist

Chemical Name: [[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid tetraethyl ester

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Pregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μM concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.

Technical Data

M.Wt:
504.53
Formula:
C24H42O7P2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
126411-39-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Berkhout et al.
    J.Biol.Chem., 1996;271:14376
  2. Discovery of a highly active ligand of human pregnane X receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.
    Lemaire et al.
    Mol.Pharmacol., 2007;72:572
  3. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
    Jones et al.
    Mol.Pharmacol., 2000;14:27

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Citation for SR 12813

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