SR 12813

Catalog # Availability Size / Price Qty
SR 12813 | CAS No. 126411-39-0 | Pregnane X Receptor Agonists
1 Image
Description: Pregnane X receptor agonist

Chemical Name: [[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid tetraethyl ester

Purity: ≥99%

Product Details
Citations (1)

Biological Activity

SR 12813 is a pregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μM concentrations. Displays hypocholesterolemic activity via enhanced degradation of HMG-CoA reductase.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Berkhout et al.
    J.Biol.Chem., 1996;271:14376
  2. Discovery of a highly active ligand of human pregnane X receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.
    Lemaire et al.
    Mol.Pharmacol., 2007;72:572
  3. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
    Jones et al.
    Mol.Pharmacol., 2000;14:27

Product Datasheets

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Citation for SR 12813

The citations listed below are publications that use Tocris products. Selected citations for SR 12813 include:

1 Citation: Showing 1 - 1


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