SR 140333

Key Product Details

Product Description

SR 140333 is a potent NK₁ receptor antagonist (K_i = 0.74 nM. IC₅₀ = 1.6 nM). Inhibits substance P-invoked calcium mobilization and outward current (IC₅₀ = 1.3 nM); blocks NK₁-mediated nitric oxide-dependent vasodilation in vivo.

Product Specifications for SR 140333

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SR 140333

The following data is based on the product molecular weight 656.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.52 mL	7.62 mL	15.24 mL
5 mM	0.30 mL	1.52 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.52 mL
50 mM	0.03 mL	0.15 mL	0.30 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Emonds-Alt In vitro and in vivo biological activities of SR140333, a novel non-peptide tachykinin NK₁ receptor antagonist. Eur.J.Pharmacol. 1993 PMID: 7509286
• Nieuwmeyer Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of Caj J.Pharmacol.Exp.Ther. 2006 PMID: 16330493
• Oury-Donat SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line. J.Neurochem. 1994 PMID: 7510780
• Hall and Brain Inhibition by SR140333 of NK₁ tachykinin receptor-evoked, nitric oxide-dependent vasodilation in the hamster cheek pouch microvasculature in vivo. Br.J.Pharmacol. 1994 PMID: 7530573

Product Documents for SR 140333