Selective inverse agonist of retinoic acid receptor-related orphan receptor γ
= 105 nM; IC50
~320 nM). Exhibits weak activity at liver X receptor α
); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα
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Sold under license from The Scripps Research Institute.
Identification of SR2211: a potent synthetic RORγ-selective modulator.
Kumar et al.
ACS Chem.Biol., 2012;7:672