SR 2211

Catalog # Availability Size / Price Qty
4869/10
4869/50
Nuclear Receptor Antagonists Small Molecule
1 Image
Description: Selective RORγ inverse agonist

Chemical Name: 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol

Purity: ≥98%

Product Details
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Biological Activity

Selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.

Technical Data

M.Wt:
527.48
Formula:
C26H24F7N3O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1359164-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from The Scripps Research Institute.

Background References

  1. Identification of SR2211: a potent synthetic RORγ-selective modulator.
    Kumar et al.
    ACS Chem.Biol., 2012;7:672

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