Chemical Name: 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol
Biological ActivitySelective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Identification of SR2211: a potent synthetic RORγ-selective modulator.
Kumar et al.
ACS Chem.Biol., 2012;7:672
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