SR 2640 hydrochloride

Key Product Details

Product Description

SR 2640 hydrochloride is a potent and selective competitive leukotriene D₄ and E₄ receptor antagonist. Inhibits LTD₄- but not histamine-induced guinea pig ileum and trachea contraction (pA₂ = 8.7). Also inhibits LTD₄-attenuation of human PMN chemotaxis. Orally active in vivo.

Product Specifications for SR 2640 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SR 2640 hydrochloride

The following data is based on the product molecular weight 406.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.92 mL	24.58 mL	49.16 mL
2.5 mM	0.98 mL	4.92 mL	9.83 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
25 mM	0.10 mL	0.49 mL	0.98 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Bouchelouche LTD₄ increases cytosolic free calcium and inositol phosphates in human neutrophils: inhibition by the novel LTD₄ receptor antagonist, SR2640, and possible relation to modulation of chemotaxis. Agents Actions 1990 PMID: 2160189
• Thomsen and Ahnfelt-Ronne Inhibition by the LTD₄ antagonist, SR2640, of effects of LTD4 on canine polymorphonuclear leukocyte functions. Biochem.Pharmacol. 1989 PMID: 2546563
• Ahnfelt-Ronne A novel leukotriene D₄/E₄ antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur.J.Pharmacol. 1988 PMID: 2854067

Product Documents for SR 2640 hydrochloride