SR 2640 hydrochloride
Chemical Name: 2-[[3-(2-Quinolinylmethoxy)phenyl]amino]benzoic acid hydrochloride
Biological ActivityPotent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4-attenuation of human PMN chemotaxis. Orally active in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid).
Ahnfelt-Ronne et al.
LTD4 increases cytosolic free calcium and inositol phosphates in human neutrophils: inhibition by the novel LTD4 receptor antagonist, SR2640, and possible relation to modulation of chemotaxis.
Bouchelouche et al.
Agents Actions, 1990;29:299
Inhibition by the LTD4 antagonist, SR2640, of effects of LTD4 on canine polymorphonuclear leukocyte functions.
Thomsen and Ahnfelt-Ronne
Citation for SR 2640 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SR 2640 hydrochloride include:
1 Citation: Showing 1 - 1
Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2.
Authors: Wright Et al.
Biochem Biophys Res Commun 2019;520:35
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