SR 33805 oxalate

Key Product Details

Product Description

Potent Ca²⁺ channel antagonist; binds allosterically to the a₁-subunit of L-type Ca²⁺ channels (K_d = 20 pM), at a site distinct from other types of blocker. Shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. Inhibits PDGF-stimulated smooth muscle cell proliferation.

Product Specifications for SR 33805 oxalate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SR 33805 oxalate

The following data is based on the product molecular weight 654.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.53 mL	7.64 mL	15.27 mL
5 mM	0.31 mL	1.53 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.53 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Magnier-Gaubil Smooth muscle cell cycle and proliferation. Relationship between calcium influx and sarco-endoplasmic reticulum Ca²⁺ATPase regulation. J.Biol.Chem. 1996 PMID: 8910375
• Romey and Lazdunski Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, on neuronal voltage-activated Ca⁺⁺ channels. J.Pharmacol.Exp.Ther. 1994 PMID: 7996445
• Chatelain In vitro characterization of a novel Ca²⁺ entry blocker: SR 33805. Eur.J.Pharmacol. 1993 PMID: 8223943

Product Documents for SR 33805 oxalate