SR 33805 oxalate
Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[4-[[1-methyl-3-(1-methylethyl)-1H-indol-2-yl]sulfonyl]phenoxy]propyl]benzeneethanamine
Purity: ≥99%
Biological Activity
Potent Ca2+ channel antagonist; binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blocker. Shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. Inhibits PDGF-stimulated smooth muscle cell proliferation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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In vitro characterization of a novel Ca2+ entry blocker: SR 33805.
Chatelain et al.
Eur.J.Pharmacol., 1993;246:181 -
Smooth muscle cell cycle and proliferation. Relationship between calcium influx and sarco-endoplasmic reticulum Ca2+ATPase regulation.
Magnier-Gaubil et al.
J.Biol.Chem., 1996;271:27788 -
Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, on neuronal voltage-activated Ca++ channels.
Romey and Lazdunski
J.Pharmacol.Exp.Ther., 1994;271:1348
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Citation for SR 33805 oxalate
The citations listed below are publications that use Tocris products. Selected citations for SR 33805 oxalate include:
1 Citation: Showing 1 - 1
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Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.
Authors: Wu Et al.
J Neurophysiol 2008;100:1897
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