SR 33805 oxalate
Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[4-[[1-methyl-3-(1-methylethyl)-1H-indol-2-yl]sulfonyl]phenoxy]propyl]benzeneethanamine
Biological ActivityPotent Ca2+ channel antagonist; binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blocker. Shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. Inhibits PDGF-stimulated smooth muscle cell proliferation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vitro characterization of a novel Ca2+ entry blocker: SR 33805.
Chatelain et al.
Smooth muscle cell cycle and proliferation. Relationship between calcium influx and sarco-endoplasmic reticulum Ca2+ATPase regulation.
Magnier-Gaubil et al.
Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, on neuronal voltage-activated Ca++ channels.
Romey and Lazdunski
Citation for SR 33805 oxalate
The citations listed below are publications that use Tocris products. Selected citations for SR 33805 oxalate include:
1 Citation: Showing 1 - 1
Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.
Authors: Wu Et al.
J Neurophysiol 2008;100:1897
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