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SR 33805 oxalate

1806 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1806/10
SR 33805 oxalate | CAS No. 121346-33-6 | Cav1.x Channel Blockers
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Description: CaV1.x blocker; binds allosterically to distinct site

Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[4-[[1-methyl-3-(1-methylethyl)-1H-indol-2-yl]sulfonyl]phenoxy]propyl]benzeneethanamine

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent Ca2+ channel antagonist; binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blocker. Shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. Inhibits PDGF-stimulated smooth muscle cell proliferation.

Technical Data

M.Wt:
654.77
Formula:
C32H40N2O5S.C2H2O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
121346-33-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for SR 33805 oxalate

The citations listed below are publications that use Tocris products. Selected citations for SR 33805 oxalate include:

1 Citation: Showing 1 - 1

  1. Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.
    Authors: Wu Et al.
    J Neurophysiol  2008;100:1897

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