channel antagonist; binds allosterically to the a1
-subunit of L-type Ca2+
= 20 pM), at a site distinct from other types of blocker. Shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. Inhibits PDGF-stimulated smooth muscle cell proliferation.
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All Tocris products are intended for laboratory research use only.
In vitro characterization of a novel Ca2+ entry blocker: SR 33805.
Chatelain et al.
Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, on neuronal voltage-activated Ca++ channels.
Romey and Lazdunski
Smooth muscle cell cycle and proliferation. Relationship between calcium influx and sarco-endoplasmic reticulum Ca2+ATPase regulation.
Magnier-Gaubil et al.