SR 48692

Key Product Details

Product Description

SR 48692 is a neurotensin antagonist; selective for NTS₁ over NTS₂ (apparent affinity, K_e, is 36 nM for NTS₁). Competitively inhibits binding of [¹²⁵I]-neurotensin to HT29 and N1E115 cell membranes (IC₅₀ values are 15.3 and 20.4 nM respectively). Orally bioavailable.

Product Specifications for SR 48692

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SR 48692

The following data is based on the product molecular weight 587.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.52 mL	42.58 mL	85.17 mL
1 mM	1.70 mL	8.52 mL	17.03 mL
2 mM	0.85 mL	4.26 mL	8.52 mL
10 mM	0.17 mL	0.85 mL	1.70 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 31 publications citing the usage of this product.

• Oury-Donat Characterization of the effect of SR48692 on inositol monophosphate, cyclic GMP and cyclic AMP responses linked to neurotensin receptor activation in neuronal and non-neuronal cells. Br.J.Pharmacol. 1995 PMID: 8528577
• Thomas The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay. Bioorg.Med.Chem.Lett. 2009 PMID: 19195889
• Gully Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Proc.Natl.Acad.Sci.USA 1993 PMID: 8380498

Product Documents for SR 48692