Chemical Name: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
Biological ActivityRev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
Kojetin et al.
ACS Chem.Biol., 2011;6:131
Citation for SR 8278
The citations listed below are publications that use Tocris products. Selected citations for SR 8278 include:
1 Citation: Showing 1 - 1
Ligand and Target Discovery by Fragment-Based Screening in Human Cells.
Authors: Parker Et al.
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