Chemical Name: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
Biological ActivityRev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
Kojetin et al.
ACS Chem.Biol., 2011;6:131
Citation for SR 8278
The citations listed below are publications that use Tocris products. Selected citations for SR 8278 include:
1 Citation: Showing 1 - 1
Ligand and Target Discovery by Fragment-Based Screening in Human Cells.
Authors: Parker Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for SR 8278
There are currently no reviews for this product. Be the first to review SR 8278 and earn rewards!
Have you used SR 8278?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image