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SR 8278

Catalog #: 4463
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4463/10
4463/50
SR 8278 | CAS No. 1254944-66-5 | Nuclear Receptor Antagonists
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Description: Rev-Erbα antagonist

Chemical Name: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.

Technical Data

M.Wt:
361.48
Formula:
C18H19NO3S2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1254944-66-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
    Kojetin et al.
    ACS Chem.Biol., 2011;6:131

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Citation for SR 8278

The citations listed below are publications that use Tocris products. Selected citations for SR 8278 include:

1 Citation: Showing 1 - 1

  1. Ligand and Target Discovery by Fragment-Based Screening in Human Cells.
    Authors: Parker Et al.
    Cell  2017;168:527

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