SR 8278

  ( 1 citations )    
Product Datasheet
Catalog Number:4463
Chemical Name:1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
Product Details
Citations (1)
Reviews
Biological Activity
Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.
Technical Data
  • M.Wt:
    361.48
  • Formula:
    C18H19NO3S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    1254944-66-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SR 8278 include:

1 Citations: Showing 1 - 1

  1. Ligand and Target Discovery by Fragment-Based Screening in Human Cells.
    Authors: Parker Et al.
    Cell  2017;168:527

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