antagonist; inhibits Rev-Erbα
transcriptional repression (EC50
= 0.47 μ
M). Blocks activity of Rev-Erbα
agonist GSK 4112
(Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase
in HepG2 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
Kojetin et al.
ACS Chem. Biol., 2011;6:131