SRPIN340

Biological Activity

Selective serine arginine protein kinase (SRPK) 1 inhibitor (K_i = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Down-regulates expression of VEGF₁₆₅ but does not affect VEGF_165b expression.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity.
   Gammons et al.
   Invest.Ophthalmol.Vis.Sci., 2013;54:5797
2. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication.
   Fukuhara et al.
   Proc.Natl.Acad.Sci.USA, 2006;103:11329
3. SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases.
   Oltean et al.
   Biochem.Soc.Trans., 2012;40:831

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