SSR 69071

Key Product Details

Product Description

SSR 69071 is a high affinity, potent inhibitor of human leukocyte elastase (HLE) (IC₅₀ = 3.9 nM). Displays species-selectivity (K_i values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID₅₀ = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.

Product Specifications for SSR 69071

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SSR 69071

The following data is based on the product molecular weight 556.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.19 mL	35.93 mL	71.86 mL
1.25 mM	1.44 mL	7.19 mL	14.37 mL
2.5 mM	0.72 mL	3.59 mL	7.19 mL
12.5 mM	0.14 mL	0.72 mL	1.44 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Varga A novel orally active inhibitor of HLE. Eur.J.Med.Chem. 2003 PMID: 12750030
• Kapui Biochemical and pharmacological characterization of 2-(9-(2-Piperidinoethoxy)-4-oxo-4H-pyrido[1,2-α]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active ela J.Pharmacol.Exp.Ther. 2003 PMID: 12606659
• Bidouard SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury. Eur.J.Pharmacol. 2003 PMID: 12568915

Product Documents for SSR 69071