High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50
= 3.9 nM). Displays species-selectivity (Ki
values are 0.017, 1.70, 3.01, 58 and > 100 nM� for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50
= 2.8 mg/kg) and reduces infarct size in an in vivo
acute model of coronary ischemia-reperfusion injury. Orally active.
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All Tocris products are intended for laboratory research use only.
SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury.
Bidouard et al.
A novel orally active inhibitor of HLE.
Varga et al.
Biochemical and pharmacological characterization of 2-(9-(2-Piperidinoethoxy)-4-oxo-4H-pyrido[1,2-α]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active ela
Kapui et al.
The citations listed below are publications that use Tocris products. Selected citations for SSR 69071 include:
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