SSR 69071

  ( 3 citations )    
Product Datasheet
Catalog Number:2506
Chemical Name:2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one
Product Details
Citations (3)
Reviews
Biological Activity
High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.
Technical Data
  • M.Wt:
    556.63
  • Formula:
    C27H32N4O7S
  • Solubility:
    Soluble to 10 mM in ethanol and to 25 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    344930-95-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SSR 69071 include:

3 Citations: Showing 1 - 3
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  1. Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase.
    Authors: Li Et al.
    PLoS One  2013;8:e72563
  2. Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation.
    Authors: Reardon Et al.
    Immunity  2011;35:223
  3. Pivotal role for alpha1-antichymotrypsin in skin repair.
    Authors: Hoffmann Et al.
    J Biol Chem  2011;286:28889

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