SSR 69071

Catalog # Availability Size / Price Qty
2506/10
SSR 69071 | CAS No. 344930-95-6 | Synthetic Elastase Inhibitors
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Description: Potent, orally active human leukocyte elastase inhibitor

Chemical Name: 2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.

Technical Data

M.Wt:
556.63
Formula:
C27H32N4O7S
Solubility:
Soluble to 10 mM in ethanol and to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
344930-95-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SSR 69071

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