Chemical Name: 2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one
Biological ActivitySSR 69071 is a high affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury.
Bidouard et al.
A novel orally active inhibitor of HLE.
Varga et al.
Biochemical and pharmacological characterization of 2-(9-(2-Piperidinoethoxy)-4-oxo-4H-pyrido[1,2-α]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active ela
Kapui et al.
Citations for SSR 69071
The citations listed below are publications that use Tocris products. Selected citations for SSR 69071 include:
3 Citations: Showing 1 - 3
Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase.
Authors: Li Et al.
PLoS One 2013;8:e72563
Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation.
Authors: Reardon Et al.
Pivotal role for alpha1-antichymotrypsin in skin repair.
Authors: Hoffmann Et al.
J Biol Chem 2011;286:28889
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