Chemical Name: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Biological ActivityST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.
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Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.
Brust et al.
Citations for ST 034307
The citations listed below are publications that use Tocris products. Selected citations for ST 034307 include:
3 Citations: Showing 1 - 3
A selective adenylyl cyclase 1 inhibitor relieves pain without causing tolerance.
Authors: Giacoletti Et al.
Cross-talk between cAMP and Ca2+ signalling in cardiac pacemaker cells involves IP3-evoked Ca2+ release and stimulation of adenylyl cyclase 1.
Authors: Bose Et al.
BioRXiv - not yet peer reviewed 2021;
Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats.
Authors: Cheng Et al.
Arch Oral Biol. 2019;98:81
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