ST 034307

Catalog # Availability Size / Price Qty
ST 034307 | CAS No. 133406-29-8 | Adenylyl Cyclase Inhibitors
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Description: Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

Chemical Name: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (3)

Biological Activity

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ST 034307

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