ST 034307

Tocris Bioscience | Catalog # 6271

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo
Tocris Bioscience

Key Product Details

Description

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo
View all Adenylyl Cyclase Inhibitors »

Product Description

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.

Product Specifications for ST 034307

Molecular Weight

297.95

Formula

C10H4Cl4O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one

CAS Number

133406-29-8

PubChem ID

867466

InChI Key

NTDHYMSVCBGQJF-UHFFFAOYSA-N

SMILES

ClC1=CC=C2OC(C(Cl)(Cl)Cl)=CC(C2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.8 100
Ethanol 5.96 20

Preparing Stock Solutions for ST 034307

The following data is based on the product molecular weight 297.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.78 mL 33.56 mL
5 mM 0.67 mL 3.36 mL 6.71 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for ST 034307

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ST 034307

For research use only

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