STARD10 Antibody - BSA Free
Novus Biologicals | Catalog # NBP3-18372
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Key Product Details
Species Reactivity
Human
Applications
Immunoprecipitation
Label
Unconjugated
Antibody Source
Polyclonal Rabbit IgG
Format
BSA Free
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Product Specifications
Immunogen
Recognizes region between residues Between Between 241 and 291..
Clonality
Polyclonal
Host
Rabbit
Isotype
IgG
Scientific Data Images for STARD10 Antibody - BSA Free
Immunoprecipitation:[NBP3-18372]-
Immunoprecipitation:[NBP3-18372]-Detection of human STARD10 by western blot of immunoprecipitates. Samples: Whole cell lysate from 293T cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-STARD10 antibody used for IP at 6 µg per reaction. STARD10 was also immunoprecipitated by rabbit anti-STARD10 antibody. For blotting immunoprecipitated STARD10, was used at 0. 4 mg/ml0. Detection: Chemiluminescence with an exposure time of 3 minutes.Applications for STARD10 Antibody - BSA Free
Application
Recommended Usage
Immunoprecipitation
8 - 15 ug/mg lysate
Formulation, Preparation, and Storage
Purification
Affinity purified
Formulation
Tris-citrate/phosphate pH 7 -8.
Format
BSA Free
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C. Do not freeze.
Background: STARD10
STARD10 is broadly expressed in different organs and tissues such as the brain, endocrine tissues, liver, and gastrointestinal tract. STARD10 is regulated by Casein kinase II, which phosphorylates STARD10 at serine 284 leading to decreased lipid transfer activity and reduced membrane association. STARD10 is overexpressed in breast carcinoma cell lines and in primary breast cancers (3). STARD10 has been implicated in the regulation of bile acid homeostasis and more recently in the regulation of insulin secretion from beta-cells (1, 2, 4).
References
1. Alpy, F., & Tomasetto, C. (2005). Give lipids a START: The StAR-related lipid transfer (START) domain in mammals. Journal of Cell Science. https://doi.org/10.1242/jcs.02485
2. Alpy, F., Legueux, F., Tomasetto, C., & Bianchetti, L. (2009). START domain-containing proteins: A review of their role in lipid transport and exchange. Medecine/Sciences. https://doi.org/10.1051/medsci/2009252181
3. Olayioye, M. A., Hoffmann, P., Pomorski, T., Armes, J., Simpson, R. J., Kemp, B. E.,... Visvader, J. E. (2004). The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-03-3731
4. Carrat, G. R., Hu, M., Nguyen-Tu, M. S., Chabosseau, P., Gaulton, K. J., van de Bunt, M.,... Rutter, G. A. (2017). Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2017.01.011
Long Name
StAR Related Lipid Transfer Domain Containing 10
Alternate Names
CGI-52, NY-CO-28, PCTP-L, PCTP2, SDCCAG28
Gene Symbol
STARD10
Additional STARD10 Products
Product Documents for STARD10 Antibody - BSA Free
Certificate of Analysis
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Product Specific Notices for STARD10 Antibody - BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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Protocols
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