STF 118804

Catalog # Availability Size / Price Qty
5207/25
5207/5
STF 118804 | CAS No. 894187-61-2 | NAMPT Inhibitors
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Description: NAMPT inhibitor; depletes leukemia stem cells

Chemical Name: 4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

STF 118804 is a NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.

Technical Data

M.Wt:
461.53
Formula:
C25H23N3O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
894187-61-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for STF 118804

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It works well for cell culture.
By Anonymous on 05/07/2020
Application: Species: Human

After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.

PMID: 31439867 Reference

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