Catalog Number: 5570
Chemical Name: 7-Ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine
Biological Activity
Lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively.
Technical Data
  • M.Wt:
    333.38
  • Formula:
    C20H19N3O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    332922-63-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.
    Mori et al.
    Biochem.J., 2013;455:339

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