Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β
-cells in vivo
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Alkylation of DNA in rat tissues following administration of streptozotocin.
Bennett and Pegg
Cancer Res., 1981;41:2786
Steptozotocin: A review of its pharmacology, efficacy and toxicity.
Cancer Treat. Rep., 1982;66:427