Stressin I

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1608
Alternate Names:cyclo(31-34)[D-Phe12,Nle21,38,Glu31, Lys34]Ac-hCRF (4-41)
Chemical Name:
Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity
Potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.
Technical Data
  • M.Wt:
    4472.24
  • Formula:
    C203H337N57O56
  • Sequence:
    PPISLDLTFHLLREVLEXARAEQLAQQEHSKRKLXEII

    (Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the SALK Institute
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Stressin I include:

2 Citations: Showing 1 - 2
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  1. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
    Authors: Silberman and Winder
    Neuropharmacology  2013;70:316
  2. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
    Authors: Land Et al.
    J Neurosci  2008;28:407

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Average Rating: 5 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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