Stressin I

Tocris Bioscience | Catalog # 1608

CRF1 agonist
Tocris Bioscience

Key Product Details

Description

CRF1 agonist

Alternative Names

cyclo(31-34)[D-Phe12,Nle21,38,Glu31,Lys34]Ac-hCRF (4-41)
View all CRF1 Receptor Agonists »

Product Description

Stressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.

Licensing Information

Sold with the permission of the SALK Institute

Product Specifications for Stressin I

Molecular Weight

4472.24

Formula

C203H337N57O56

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

935739-46-1

PubChem ID

90479815

InChI Key

HZKFMBAUDWRPRY-WNBAZHKDSA-N

SMILES

CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(C)=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for Stressin I

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Stressin I

For research use only

Customer Reviews for Stressin I (1)

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  • Stressin 1 modulation of GABA transmission
    Name: Anonymous
    Assay Type: In Vitro
    Verified Customer | Posted 05/10/2018
    Exogenous application of various concentrations onto acute brain slices was used to examine CRF1 receptor modulation of GABA transmission in the central amygdala.

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