Stressin I

Catalog # Availability Size / Price Qty
Stressin I
1 Image
Description: CRF1 agonist
Alternative Names: cyclo(31-34)[D-Phe12,Nle21,38,Glu31, Lys34]Ac-hCRF (4-41)

Purity: ≥95%

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Stressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.

Technical Data


(Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the SALK Institute

Background References

  1. CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior.
    Bruchas et al.
    PLoS One., 2009;4:e8528
  2. Stressin1-A, a potent cortico. releasing factor receptor 1 (CRF1)-selective peptide agonist.
    Rivier et al.
    J.Med.Chem., 2007;50:1668
  3. Receptor-selective cortico. releasing factor analogs.
    Rivier et al.
    Endocrin.Soc.Abstr., 2002;:P2-50

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Stressin I

The citations listed below are publications that use Tocris products. Selected citations for Stressin I include:

2 Citations: Showing 1 - 2


No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for Stressin I

Average Rating: 5 (Based on 1 Review)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used Stressin I?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Stressin 1 modulation of GABA transmission
By Anonymous on 05/10/2018

Exogenous application of various concentrations onto acute brain slices was used to examine CRF1 receptor modulation of GABA transmission in the central amygdala.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.