Biological ActivityStressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.
(Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior.
Bruchas et al.
PLoS One., 2009;4:e8528
Stressin1-A, a potent cortico. releasing factor receptor 1 (CRF1)-selective peptide agonist.
Rivier et al.
Receptor-selective cortico. releasing factor analogs.
Rivier et al.
Citations for Stressin I
The citations listed below are publications that use Tocris products. Selected citations for Stressin I include:
2 Citations: Showing 1 - 2
Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
Authors: Silberman and Winder
The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Authors: Land Et al.
J Neurosci 2008;28:407
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Exogenous application of various concentrations onto acute brain slices was used to examine CRF1 receptor modulation of GABA transmission in the central amygdala.