Catalog Number: 1608
Alternate Names: cyclo(31-34)[D-Phe12,Nle21,38,Glu31, Lys34]Ac-hCRF (4-41)
Biological Activity
Potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the SALK Institute
Background References
  1. CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior.
    Bruchas et al.
    PLoS One., 2009;4:e8528
  2. Stressin1-A, a potent corticotropin releasing factor receptor 1 (CRF1)-selective peptide agonist.
    Rivier et al.
    J.Med.Chem., 2007;50:1668
  3. Receptor-selective corticotropin releasing factor analogs.
    Rivier et al.
    Endocrin.Soc.Abstr., 2002;:P2-50

The citations listed below are publications that use Tocris products. Selected citations for Stressin I include:

Showing Results 1 - 1 of 1

  1. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
    Authors: Land Et al.
    J Neurosci
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