Chemical Name: 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Biological ActivityPotent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Citations for SU 16f
The citations listed below are publications that use Tocris products. Selected citations for SU 16f include:
4 Citations: Showing 1 - 4
Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth.
Authors: Chatterjee Et al.
A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion.
Authors: Jiang Et al.
Nat Commun 2017;8:15926
Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells.
Authors: Andersen Et al.
Proc Natl Acad Sci U S A 2015;6:196
Lymphatic endothelial cells support tumor growth in breast cancer.
Authors: Lee Et al.
Sci Rep 2014;4:5853
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