SU 16f

Key Product Details

Product Description

SU 16f is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC₅₀ = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC₅₀ = 0.11 μM). Promotes conversion of fibroblasts to cardiomyocytes as part of 9C cocktail (see our protocol below).

For more information about how SU 16f may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

Product Specifications for SU 16f

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SU 16f

The following data is based on the product molecular weight 386.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.94 mL	25.88 mL
5 mM	0.52 mL	2.59 mL	5.18 mL
10 mM	0.26 mL	1.29 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 41 publications citing the usage of this product.

• Cao Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 2016 PMID: 27127239
• Sun Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 1999 PMID: 10602697

Product Documents for SU 16f