Potent and selective platelet-derived growth factor receptor β
) inhibitor (IC50
= 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro
= 0.11 μ
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All Tocris products are intended for laboratory research use only.
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Sun et al.
The citations listed below are publications that use Tocris products. Selected citations for SU 16f include:
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