Chemical Name: 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Biological ActivitySU 16f is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM). Promotes conversion of fibroblasts to cardiomyocytes as part of 9C cocktail.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Conversion of human fibroblasts into functional cardiomyocytes by small molecules.
Cao et al.
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Sun et al.
Citations for SU 16f
The citations listed below are publications that use Tocris products. Selected citations for SU 16f include:
4 Citations: Showing 1 - 4
Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth.
Authors: Chatterjee Et al.
A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion.
Authors: Jiang Et al.
Nat Commun 2017;8:15926
Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells.
Authors: Andersen Et al.
Proc Natl Acad Sci U S A 2015;6:196
Lymphatic endothelial cells support tumor growth in breast cancer.
Authors: Lee Et al.
Sci Rep 2014;4:5853
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