SU 5416

  ( 10 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3037
Alternate Names:Semaxinib
Chemical Name:3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
Product Details
Citations (10)
Supplemental Products
Reviews
Biological Activity
Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types.
Technical Data
  • M.Wt:
    238.28
  • Formula:
    C15H14N2O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at -20°C
  • CAS No:
    204005-46-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SU 5416 include:

10 Citations: Showing 1 - 10
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  1. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.
    Authors: Hurst
    Nat Commun  2017;8:14079
  2. Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension.
    Authors: Meloche Et al.
    Arterioscler Thromb Vasc Biol  2017;37:1513
  3. Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats.
    Authors: Happ&eacute Et al.
    Am J Physiol Lung Cell Mol Physiol  2016;310:L1088
  4. Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma.
    Authors: Azzi Et al.
    Pulm Circ  2015;6:281
  5. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.
    Authors: Long Et al.
    Nat Med  2015;21:777
  6. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension.
    Authors: Chabon Et al.
    J Neurophysiol  2014;4:289
  7. KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.
    Authors: DiStefano Et al.
    J Biol Chem  2014;289:33054
  8. Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum.
    Authors: Hempel Et al.
    Malar J  2014;13:201
  9. Reversal of severe angioproliferative pulmonary arterial hypertension and right ventricular hypertrophy by combined phosphodiesterase-5 and endothelin receptor inhibition.
    Authors: Cavasin Et al.
    J Transl Med  2014;12:314
  10. Anti-vascular endothelial growth factor treatment in combination with chemotherapy delays hematopoietic recovery due to decreased proliferation of bone marrow hematopoietic progenitor cells.
    Authors: Novitskiy Et al.
    J Thorac Oncol  2010;5:1410

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VersaClone cDNA Plasmids
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Average Rating: 5 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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