SU 5416

Catalog # Availability Size / Price Qty
SU 5416 | CAS No. 204005-46-9 | VEGF Receptor Inhibitors
1 Image
Description: VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
Alternative Names: Semaxinib

Chemical Name: 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one

Purity: ≥99%

Product Details
Citations (12)
Supplemental Products
Reviews (1)

Biological Activity

SU 5416, an angiogenesis inhibitor, is a potent vascular endothelial growth factor receptor tyrosine kinase 1/2 inhibitor (IC50 = 40 nM). SU 5416 also potently inhibits c-Kit, FLT3 and RET tyrosine kinases (IC50 values are 30 nM, 160 nM and 170 nM, respectively). SU 5416 shows inhibition of tumour growth and vascularization and can be used to generate an animal model of pulmonary arterial hypertension.

Technical Data

Soluble to 100 mM in DMSO
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SU 5416

The citations listed below are publications that use Tocris products. Selected citations for SU 5416 include:

12 Citations: Showing 1 - 10

  1. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.
    Authors: Longchamp Et al.
    Cell  2018;173:117
  2. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.
    Authors: Hurst
    Nat Commun  2017;8:14079
  3. Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension.
    Authors: Meloche Et al.
    Arterioscler Thromb Vasc Biol  2017;37:1513
  4. Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition.
    Authors: Neto-Neves Et al.
    Am J Pathol  2017;187:700
  5. Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats.
    Authors: Happ&eacute Et al.
    Am J Physiol Lung Cell Mol Physiol  2016;310:L1088
  6. Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma.
    Authors: Azzi Et al.
    Pulm Circ  2015;6:281
  7. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.
    Authors: Long Et al.
    Nat Med  2015;21:777
  8. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension.
    Authors: Chabon Et al.
    J Neurophysiol  2014;4:289
  9. KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.
    Authors: DiStefano Et al.
    J Biol Chem  2014;289:33054
  10. Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum.
    Authors: Hempel Et al.
    Malar J  2014;13:201


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By Anonymous on 12/01/2017

We study rodent models of pulmonary hypertension where we inject SU5416 in addition to placing the animals in hypoxia to exacerbate the PH phenotype

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