SU 9516

Discontinued Product

2907 has been discontinued.
View all Cyclin-dependent Kinase Inhibitors products.
SU 9516 | CAS No. 377090-84-1 | Cyclin-dependent Kinase Inhibitors
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Description: Cdk inhibitor; potently inhibits cdk1 and cdk2

Chemical Name: (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one

Purity: ≥99%

Product Details
Citations (2)

Biological Activity

SU 9516 is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.02 - 0.03, 0.04 - 0.2, 0.2 - 1.7 and 0.9 μM for cdk2, cdk1, cdk4 and cdk9, respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects in vitro.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SU 9516

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