High affinity D2
receptor agonist (EC50
values are between 17 and 75 nM in cell-based assays). Displays >200-fold selectivity for the D2
receptor against other dopamine receptor subtypes (Ki
values are 9.0, 1940, >2190 and >7140 for D2
receptors respectively). Exhibits antiParkinsonian activity similar to ropinirole
(Cat. No. 3680).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Sumanirole, a highly dopamine D2-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's disease.
McCall et al.
The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys.
Stephenson et al.