High affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (Ki
= 0.1 nM). Increases PGE2
levels in A549 cells in vitro
, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.
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Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Zhang et al.