SX 011

Key Product Details

Product Description

Potent p38α inhibitor (IC₅₀ = 9 nM). Also inhibits p38β and JNK-2 (IC₅₀ values are 90 nM and 100 nM respectively). Displays no significant activity at p38γ, p38δ, ERK-2 and JNK-1.

Product Specifications for SX 011

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SX 011

The following data is based on the product molecular weight 483.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.33 mL	20.66 mL
5 mM	0.41 mL	2.07 mL	4.13 mL
10 mM	0.21 mL	1.03 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lee and Dominguez MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr.Med.Chem. 2005 PMID: 16378500

Product Documents for SX 011