SZL P1-41

   
Product Datasheet
Catalog Number:5076
Chemical Name:3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Product Details
Reviews
Biological Activity
Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.
Technical Data
  • M.Wt:
    420.52
  • Formula:
    C24H24N2O3S
  • Solubility:
    Soluble to 20 mM in 1eq. HCl and to 5 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    222716-34-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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