SZL P1-41

Catalog # Availability Size / Price Qty
5076/10
5076/50
SZL P1-41 | CAS No. 222716-34-9 | Ubiquitin Ligase (E3) Inhibitors
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Description: Selective Skp2 inhibitor; suppresses E3 ligase activity

Chemical Name: 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

SZL P1-41 is a Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

Technical Data

M.Wt:
420.52
Formula:
C24H24N2O3S
Solubility:
Soluble to 20 mM in 1eq. HCl and to 5 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
222716-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for SZL P1-41

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