Chemical Name: 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Biological ActivitySZL P1-41 is a Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.
Chan et al.
Citation for SZL P1-41
The citations listed below are publications that use Tocris products. Selected citations for SZL P1-41 include:
1 Citation: Showing 1 - 1
Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling.
Authors: Jang Et al.
EMBO J 2017;36:2510
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for SZL P1-41
There are currently no reviews for this product. Be the first to review SZL P1-41 and earn rewards!
Have you used SZL P1-41?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image