T 3364366

Key Product Details

Product Description

T 3364366 is a potent and reversible fatty acid desaturase 1 (FADS1; Δ⁵ desaturase) inhibitor (IC₅₀ values are 1.9 nM and 2.1 nM in human and rat hepatocyte cell lines, respectively). Exhibits >300 fold selectivity for FADS1 over FADS2 (Δ⁶ desaturase). Inhibits arachidonic acid production in rat and human hepatocyte cell lines. Orally bioavailable.

Product Specifications for T 3364366

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for T 3364366

The following data is based on the product molecular weight 443.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.25 mL	11.27 mL	22.55 mL
5 mM	0.45 mL	2.25 mL	4.51 mL
10 mM	0.23 mL	1.13 mL	2.25 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Miyahisa T-3364366 targets the desaturase domain of delta-5 desaturase with nanomolar potency and a multihour residence time. ACS Med.Chem.Lett. 2016 PMID: 27660693

Product Documents for T 3364366