T 3364366

Catalog # Availability Size / Price Qty
6106/10
6106/50
Cat.No. 6106 - T 3364366 | C18H16F3N3O3S2 | CAS No. 1356354-09-0
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Description: Potent and reversible FADS1 inhibitor; orally bioavailable

Chemical Name: N-[2-[[3,4-Dihydro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]thio]ethyl]acetamide

Purity: ≥98%

Product Details
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Biological Activity

Potent and reversible fatty acid desaturase 1 (FADS1; Δ5 desaturase) inhibitor (IC50 values are 1.9 nM and 2.1 nM in human and rat hepatocyte cell lines, respectively). Exhibits >300 fold selectivity for FADS1 over FADS2 (Δ6 desaturase). Inhibits arachidonic acid production in rat and human hepatocyte cell lines. Orally bioavailable.

Technical Data

M.Wt:
443.46
Formula:
C18H16F3N3O3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1356354-09-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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