Chemical Name: 4-[[trans-4-[[[[4-(Trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]benzoic acid
Biological ActivityPotent soluble epoxide hydrolase (sEH) Inhibitor (IC50 = 0.9 nM). Enhances hepatic eNOS phosphorylation and NO release. Exhibits antihypertensive and cardioprotective actions in cirrhotic rat models. Suppress the activation of HSCs and reduce hepatic fibrosis through inhibition of NF-κB/IκBα signaling. Anti-inflammatory and antinociceptive.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Orally bioavailable potent soluble epoxide hydrolase inhibitors.
Hwang et al.
Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis.
Deng et al.
Prostaglandins Other Lipid Mediat., 2017;131:67
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for t-TUCB
There are currently no reviews for this product. Be the first to review t-TUCB and earn rewards!
Have you used t-TUCB?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image