T16Ainh - A01

Key Product Details

Product Description

T16Ainh - A01 is an inhibitor of Ca²⁺-dependent Cl^- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC₅₀ = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro.

Product Specifications for T16Ainh - A01

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for T16Ainh - A01

The following data is based on the product molecular weight 416.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.40 mL	12.00 mL	24.01 mL
5 mM	0.48 mL	2.40 mL	4.80 mL
10 mM	0.24 mL	1.20 mL	2.40 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

• Mroz and Keely Epidermal growth factor chronically upregulates Ca²⁺-dependent Cl^- conductance and TMEM16A expression in intestinal epithelial cells. J.Physiol. 2012 PMID: 22351639
• Duvvuri TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res. [Epub ahead of print] 2012 PMID: 22564524
• Namkung TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 2011 PMID: 21084298

Product Documents for T16Ainh - A01