Chemical Name: (βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
Biological ActivityT2AA is a proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.
Punchihewa C, Inoue A, Hishiki A et al.
J Biol Chem
Citation for T2AA
The citations listed below are publications that use Tocris products. Selected citations for T2AA include:
1 Citation: Showing 1 - 1
Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo.
Authors: Carl L Et al.
Cell Rep 2020;30:1329-1341.e5
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