T2AA

Tocris Bioscience | Catalog # 4723

PCNA inhibitor
Tocris Bioscience
Discontinued Product
4723 has been discontinued. View all DNA, RNA and Protein Synthesis Inhibitors products.

Key Product Details

Description

PCNA inhibitor
View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.

Licensing Information

Sold under license from St. Jude Childrens Research Hospital

Product Specifications for T2AA

Molecular Weight

511.09

Formula

C15H15I2NO3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol

CAS Number

1380782-27-3

PubChem ID

71185540

InChI Key

NKOSKXJRVWVXRI-JTQLQIEISA-N

SMILES

IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.11 100

Preparing Stock Solutions for T2AA

The following data is based on the product molecular weight 511.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.78 mL 19.57 mL
5 mM 0.39 mL 1.96 mL 3.91 mL
10 mM 0.20 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.20 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for T2AA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for T2AA

For research use only

Customer Reviews for T2AA (1)

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  • T2AA completely kills melanoma cell line at micromolar concentrations
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: SK-MEL-28
    Verified Customer | Posted 02/07/2019
    Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).
    T2AA 4723

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