TAK 375

Tocris Bioscience | Catalog # 6777

Very high affinity and selective melatonin receptor agonist
Tocris Bioscience

Key Product Details

Description

Very high affinity and selective melatonin receptor agonist

Alternative Names

Ramelteon
View all Melatonin (MT) Receptor Agonists »

Product Description

TAK 375 is a very high affinity and selective melatonin agonist (Ki values are 14 and 112 pM for human MT1 and MT2, respectively). Selective for human MT1 and MT2 over hamster MT3 and a range of other targets including benzodiazepine, opiate and dopamine receptors, ion channels and transporters. Accelerates return to normal circadian rhythm in rats after phase shift, without affecting learning and memory. Also reduces infarct size in rat heart in vitro post ischemia-reperfusion.

Product Specifications for TAK 375

Molecular Weight

259.34

Formula

C16H21NO2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide

CAS Number

196597-26-9

PubChem ID

208902

InChI Key

YLXDSYKOBKBWJQ-LBPRGKRZSA-N

SMILES

CCC(NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.93 100
Ethanol 25.93 100

Preparing Stock Solutions for TAK 375

The following data is based on the product molecular weight 259.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.28 mL 38.56 mL
5 mM 0.77 mL 3.86 mL 7.71 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TAK 375

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TAK 375

For research use only

Customer Reviews for TAK 375 (1)

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  • Activates the MT receptors
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Cancer and primary liver cell lines
    Verified Customer | Posted 04/07/2022
    I used TAK 375 for cell growth analysis and western blotting analysis
    TAK 375 6777

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