Chemical Name: N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide
Biological ActivityTAK 375 is a very high affinity and selective melatonin agonist (Ki values are 14 and 112 pM for human MT1 and MT2, respectively). Selective for human MT1 and MT2 over hamster MT3 and a range of other targets including benzodiazepine, opiate and dopamine receptors, ion channels and transporters. Accelerates return to normal circadian rhythm in rats after phase shift, without affecting learning and memory. Also reduces infarct size in rat heart in vitro post ischemia-reperfusion.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats
Hirai et al.
Melatonin receptor agonist rame. reduces ischemia-reperfusion injury through activation of mitochondrial potassium channels.
Stroethoff et al.
Neurochemical properties of rame. (TAK-375), a selective MT1/MT2 receptor agonist.
Kato et al.
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