TAK 375

Catalog # Availability Size / Price Qty
6777/10
6777/50
Melatonin (MT) Receptor Agonists Small Molecule
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Description: Very high affinity and selective melatonin receptor agonist
Alternative Names: Ramelteon

Chemical Name: N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide

Purity: ≥98%

Product Details
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Biological Activity

Very high affinity and selective melatonin agonist (Ki values are 14 and 112 pM for human MT1 and MT2, respectively). Selective for human MT1 and MT2 over hamster MT3 and a range of other targets including benzodiazepine, opiate and dopamine receptors, ion channels and transporters. Accelerates return to normal circadian rhythm in rats after phase shift, without affecting learning and memory. Also reduces infarct size in rat heart in vitro post ischemia-reperfusion.

Technical Data

M.Wt:
259.34
Formula:
C16H21NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
196597-26-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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