Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester
Biological ActivityTalniflumate is a calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome.
Walker et al.
Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats.
Sanchez et al.
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Activity evaluation of Talniflumate carried out. Human pancreatic cancer cell line MIA PaCa and BxPC-3 were used.