Talniflumate

Catalog # Availability Size / Price Qty
2510/10
2510/50
Talniflumate | CAS No. 66898-62-2 | Calcium-activated Chloride Channel Blockers
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Description: CaCC blocker and Cl-/HCO3- exchange inhibitor

Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

Calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

Technical Data

M.Wt:
414.34
Formula:
C21H13F3N2O4
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
66898-62-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome.
    Walker et al.
    J.Pharmacol.Exp.Ther., 2006;317:275
  2. Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats.
    Sanchez et al.
    J.Appl.Toxicol., 1982;2:42
  3. Talniflumate (Genaera).
    Knight
    Curr.Opin.Invest.Drugs, 2004;5:557

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Activity evaluation of Talniflumate carried out.
By Anonymous on 08/26/2019
Species: Human

Activity evaluation of Talniflumate carried out. Human pancreatic cancer cell line MIA PaCa and BxPC-3 were used.


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