Catalog Number: 2510
Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester
Biological Activity
Calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome.
    Walker et al.
    J.Pharmacol.Exp.Ther., 2006;317:275
  2. Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats.
    Sanchez et al.
    J.Appl.Toxicol., 1982;2:42
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