Calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-
exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
Soluble to 25 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome.
Walker et al.
Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats.
Sanchez et al.