Tanshinone IIA

Key Product Details

Product Description

Tanshinone IIA is a major tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Displays antioxidant and anti-inflammatory properties.

Product Specifications for Tanshinone IIA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Tanshinone IIA

The following data is based on the product molecular weight 294.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	67.95 mL	339.74 mL	679.49 mL
0.25 mM	13.59 mL	67.95 mL	135.90 mL
0.5 mM	6.79 mL	33.97 mL	67.95 mL
2.5 mM	1.36 mL	6.79 mL	13.59 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Dong Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Mol.Biol.Rep. 2012 PMID: 22314911
• Wang Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J.Neurooncol. 2007 PMID: 16955220
• Jin Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J.Cell Biochem. 2008 PMID: 17979138
• Lee Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol.Cancer Ther. 2008 PMID: 19001436

Product Documents for Tanshinone IIA