Catalog Number: 4426
Chemical Name: 6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione
Biological Activity
Major tanshinone isolated from Salvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Displays antioxidant and anti-inflammatory properties.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway.
    Dong et al.
    Mol.Biol.Rep., 2012;39:6495
  2. Anticancer effects of tanshinone I in human non-small cell lung cancer.
    Lee et al.
    Mol.Cancer Ther., 2008;7:3527
  3. Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells.
    Wang et al.
    J.Neurooncol., 2007;82:11
  4. Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway.
    Jin et al.
    J.Cell Biochem., 2008;104:15
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