TAPI 0

Tocris Bioscience | Catalog # 5523

ADAM-17 (TACE) and MMP inhibitor
Tocris Bioscience

Key Product Details

Description

ADAM-17 (TACE) and MMP inhibitor

Alternative Names

TNF-α processing inhibitor-0
View all Synthetic Metalloprotease Inhibitors »

Product Description

TAPI 0 is an ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 (Cat. No. 2983) to inhibit Chlamydia trachomatis growth.

This product is typically reconstituted in DMSO.

Product Specifications for TAPI 0

Molecular Weight

456.54

Formula

C24H32N4O5

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide

CAS Number

163958-73-4

PubChem ID

3035404

InChI Key

CRCPLBFLOSEABN-VBSNWNEZSA-N

SMILES

ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(N)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for TAPI 0

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TAPI 0

For research use only

Customer Reviews for TAPI 0 (1)

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  • In vitro cell treatment
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 01/04/2019
    Cells were treated with 10 um TAPI-0 to study cell surface protein shedding

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