TAT-Gap19(I130A)

Name: TAT-Gap19(I130A)
Brand: Tocris Bioscience
SKU: 7402
Price: 322 USD
Availability: InStock

Tocris Bioscience | Catalog # 7402

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Product Documents

Control peptide for TAT-Gap19

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Control peptide for TAT-Gap19

View all Gap Channel Blockers »

Product Description

TAT-Gap19(I130A) is a control peptide for TAT-Gap19 (Cat. No. 6227), a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca²⁺]_i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable.

Product Specifications for TAT-Gap19(I130A)

Molecular Weight

2661.20

Formula

C₁₁₆H₂₀₆N₄₆O₂₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

InChI Key

JIFBPYPLZXITDC-KYILVESISA-N

SMILES

O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Mass

Concentration

Volume

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g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Walrave Inhibition of connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory. Front.Cell Neurosci. 2016 PMID: 28066184
Wang Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 2013 PMID: 23184389

Product Documents for TAT-Gap19(I130A)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for TAT-Gap19(I130A)

For research use only

Related Research Areas

Ion Channels and Regulators

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