Biological ActivityTAT-Gap19 is a Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 (Cat. No. 5353). Active in vivo. Brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.
Abudara et al.
Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1.
Freitas-Andrade and Naus
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VersaClone cDNA Plasmids
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