receptor inverse agonist selective for the α5
values are 1.6, 16, 20 and 20 nM for α
1 and α
3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.
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Identification of a novel, selective GABA5 α5 receptor inverse agonist which enhances cognition.
Chambers et al.
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