Chemical Name: 6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one
Biological ActivityTB 21007 is a GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a novel, selective GABA5 α5 receptor inverse agonist which enhances cognition.
Chambers et al.
Citations for TB 21007
The citations listed below are publications that use Tocris products. Selected citations for TB 21007 include:
2 Citations: Showing 1 - 2
Blockade of spinal α5-GABAA receptors differentially reduces reserpine-induced fibromyalgia-type pain in female rats.
Authors: De la Luz-Cuellar Et al.
Eur J Pharmacol 2019;858:172443
Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.
Authors: Koh Et al.
J Clin Invest 2013;64:145
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