Catalog Number: 2905
Chemical Name: 6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one
Biological Activity
GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.
Technical Data
  • M.Wt:
    339.5
  • Formula:
    C15H17NO2S3
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    207306-50-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a novel, selective GABA5 α5 receptor inverse agonist which enhances cognition.
    Chambers et al.
    J.Med.Chem., 2003;46:2227
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TB 21007 include:

1 Citations: Showing 1 - 1

  1. Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.
    Authors: Koh Et al.
    J Clin Invest 2013;64:145

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