A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC50
= 0.9 and 1.6 μ
M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with Ki
values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.
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All Tocris products are intended for laboratory research use only.
Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').
Sarno et al.
FEBS Lett., 2001;496:44
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Pagano et al.
Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.
Zien et al.
The citations listed below are publications that use Tocris products. Selected citations for TBB include:
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