Catalog Number: 2275
Alternate Names: NSC 231634
Chemical Name: 4,5,6,7-Tetrabromobenzotriazole
Biological Activity
A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.
Technical Data
  • M.Wt:
    434.71
  • Formula:
    C6HBr4N3
  • Solubility:
    Soluble to 100 mM in DMSO and to 15 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    17374-26-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').
    Sarno et al.
    FEBS Lett., 2001;496:44
  2. Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
    Pagano et al.
    J.Med.Chem., 2004;47:6239
  3. Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.
    Zien et al.
    Biochim.Biophys.Acta., 2005;1754:271
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TBB include:

4 Citations: Showing 1 - 4
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  1. Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages.
    Authors: Navasa Et al.
    J Urol 2015;5:14692
  2. BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice.
    Authors: Korb Et al.
    Sci Rep 2015;18:1464
  3. The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy.
    Authors: Wu Et al.
    Autophagy 2014;10:1712
  4. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
    Authors: Buchanan Et al.
    Neuron 2010;68:948

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