Chemical Name: 4,5,6,7-Tetrabromobenzotriazole
Biological ActivityA cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').
Sarno et al.
FEBS Lett., 2001;496:44
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Pagano et al.
Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.
Zien et al.
Citations for TBB
The citations listed below are publications that use Tocris products. Selected citations for TBB include:
6 Citations: Showing 1 - 6
M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment.
Proc Natl Acad Sci U S A 2017;114(47):E10234
Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP.
Authors: Bartley Et al.
Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages.
Authors: Navasa Et al.
J Urol 2015;5:14692
BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice.
Authors: Korb Et al.
Sci Rep 2015;18:1464
The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy.
Authors: Wu Et al.
Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
Authors: Buchanan Et al.
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