TC-F 2

Key Product Details

Product Description

TC-F 2 is a potent, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC₅₀ values are 28 and 100 nM for human and rat FAAH respectively). Noncovalent inhibitor; displays selectivity for FAAH over cannabinoid-related targets (IC₅₀ > 20 μM for CB₁, CB₂ and TRPV1). Active in vivo.

Product Specifications for TC-F 2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TC-F 2

The following data is based on the product molecular weight 439.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.38 mL	22.75 mL
5 mM	0.46 mL	2.28 mL	4.55 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gustin Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors. Bioorg.Med.Chem.Lett. 2011 PMID: 21392988
• Min Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proc.Natl.Acad.Sci.U.S.A. 2011 PMID: 21502526

Product Documents for TC-F 2