Chemical Name: 3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
Biological ActivityPotent TRPM8 antagonist (IC50 values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Parks et al.
Citation for TC-I 2014
The citations listed below are publications that use Tocris products. Selected citations for TC-I 2014 include:
1 Citation: Showing 1 - 1
Structural insights into TRPM8 inhibition and desensitization.
Authors: Diver Et al.
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VersaClone cDNA Plasmids
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