TC-I 2014

Tocris Bioscience | Catalog # 5410

Potent TRPM8 antagonist
Tocris Bioscience

Key Product Details

Description

Potent TRPM8 antagonist
View all TRPM Blockers »

Product Description

TC-I 2014 is a potent TRPM8 antagonist (IC50 values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.

Product Specifications for TC-I 2014

Molecular Weight

467.41

Formula

C23H19F6N3O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

CAS Number

1221349-53-6

PubChem ID

45274257

InChI Key

GZINXHRSQAMEQY-ZZEZOPTASA-N

SMILES

FC(C(C=CC=C3)=C3C1=CC(C(F)(F)F)=C(NC(C4=NOC5(CCCCC5)C4)=N2)C2=C1)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.74 100
Ethanol 46.74 100

Preparing Stock Solutions for TC-I 2014

The following data is based on the product molecular weight 467.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.70 mL 21.39 mL
5 mM 0.43 mL 2.14 mL 4.28 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TC-I 2014

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TC-I 2014

For research use only

Related Research Areas

Ion Channels and Regulators

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