Potent TRPM8 antagonist (IC50
values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo
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All Tocris products are intended for laboratory research use only.
Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Parks et al.