TC LPA5 4
Chemical Name: 5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Biological ActivityLPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells). Inhibits LPA-induced aggregation of isolated human platelets. Exhibits selectivity for LPA5 against 80 other screened targets.
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Selective non-lipid modulator of LPA5 activity in human platelets.
Kozian et al.
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TC LPA5 4 was used in order to study the role of LPAR5 in murine microglia. The inhibitor was used in many different experimental procedures (WB, IF, qPCR, flow cytometry, functional assays) and the results were consistent..Up to 10µM the inhibitor was well tolerated by the cells. Higher concentrations have not been tested (and were not necessary).