TC LPA5 4
Chemical Name: 5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Purity: ≥98%
Biological Activity
LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells). Inhibits LPA-induced aggregation of isolated human platelets. Exhibits selectivity for LPA5 against 80 other screened targets.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selective non-lipid modulator of LPA5 activity in human platelets.
Kozian et al.
Bioorg.Med.Chem.Lett., 2012;22:5239
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Citations for TC LPA5 4
The citations listed below are publications that use Tocris products. Selected citations for TC LPA5 4 include:
2 Citations: Showing 1 - 2
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Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1.
Authors: Kittaka Et al.
J Physiol 2017;595:2681
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Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype.
Authors: Plastira Et al.
J Neuroinflammation 2017;14:253
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TC LPA5 4 was used in order to study the role of LPAR5 in murine microglia. The inhibitor was used in many different experimental procedures (WB, IF, qPCR, flow cytometry, functional assays) and the results were consistent..Up to 10µM the inhibitor was well tolerated by the cells. Higher concentrations have not been tested (and were not necessary).
