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TC LPA5 4

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TC LPA5 4 | CAS No. 1393814-38-4 | Lysophosphatidic Acid (LPA) Receptor Antagonists
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Description: LPA5 receptor antagonist

Chemical Name: 5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TC LPA5 4 is a LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells). Inhibits LPA-induced aggregation of isolated human platelets. Exhibits selectivity for LPA5 against 80 other screened targets.

Technical Data

M.Wt:
410.89
Formula:
C23H23ClN2O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1393814-38-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective non-lipid modulator of LPA5 activity in human platelets.
    Kozian et al.
    Bioorg.Med.Chem.Lett., 2012;22:5239

Product Datasheets

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Citations for TC LPA5 4

The citations listed below are publications that use Tocris products. Selected citations for TC LPA5 4 include:

2 Citations: Showing 1 - 2

  1. Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1.
    Authors: Kittaka Et al.
    J Physiol  2017;595:2681
  2. Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype.
    Authors: Plastira Et al.
    J Neuroinflammation  2017;14:253

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VersaClone cDNA Plasmids

Human LPAR5/LPA5/GPR92 (NP_065133) VersaClone cDNA

RDC0455

Reviews for TC LPA5 4

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TC LPA5 4 in the inhibition of LPA induced proinflammatory phenotype in microglia
By Joanna Plastira on 10/09/2018
Application: Species: Mouse

TC LPA5 4 was used in order to study the role of LPAR5 in murine microglia. The inhibitor was used in many different experimental procedures (WB, IF, qPCR, flow cytometry, functional assays) and the results were consistent..Up to 10µM the inhibitor was well tolerated by the cells. Higher concentrations have not been tested (and were not necessary).

Reference
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