TC-PTP/PTPN2 Antibody - BSA Free

Novus Biologicals | Catalog # NBP3-29903

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all TC-PTP Primary Antibodies »

Product Specifications

Immunogen

Between 350 and 400

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TC-PTP/PTPN2 Antibody - BSA Free

TC-PTP/PTPN2 Antibody

Immunoprecipitation:TC-PTP/PTPN2 AntibodyNBP3-29903] -

Immunoprecipitation:TC-PTP/PTPN2 AntibodyNBP3-29903] -Detection of human PTPN2 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-PTPN2 antibody NBP3-29903 (lot NBP3-29903-1) used for IP at 6 µg per reaction. PTPN2 was also immunoprecipitated by rabbit anti-PTPN2.. For blotting immunoprecipitated PTPN2, NBP3-29903 was used at 1 µg/ml. Detection: Chemiluminescence with an exposure time of 75 seconds.

Applications for TC-PTP/PTPN2 Antibody - BSA Free

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Tris-citrate/phosphate pH 7 -8.

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TC-PTP

PTPN2 is encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq]

Long Name

T Cell Protein Tyrosine Phosphatase

Alternate Names

PTP2, PTPN2, TCPTP

Gene Symbol

PTPN2

Additional TC-PTP Products

Product Documents for TC-PTP/PTPN2 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for TC-PTP/PTPN2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Epigenetics
Phosphatases and Regulators

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Protocols

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