TC-S 7001

Tocris Bioscience | Catalog # 4961

Potent and highly selective ROCK inhibitor; orally active
Tocris Bioscience

Key Product Details

Description

Potent and highly selective ROCK inhibitor; orally active

Alternative Names

Azaindole-1,BAY-549
View all Rho-kinase Inhibitors »

Product Description

TC-S 7001 (also known as BAY-549) is a potent and highly selective ROCK inhibitor (IC50 values are 0.6 and 1.1 nM for human ROCK1 and ROCK2, respectively), which exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. TC-S 7001 reduces blood pressure in normotensive and hypertensive rats, and is orally active.

External Portal Information

Chemicalprobes.org

and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of TC-S 7001 (BAY 549) is reviewed on chemicalprobes.org and the SGC website.

Product Specifications for TC-S 7001

Molecular Weight

402.79

Formula

C18H13ClF2N6O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine

CAS Number

867017-68-3

PubChem ID

11524200

InChI Key

NRSGWEVTVGZDFC-UHFFFAOYSA-N

SMILES

ClC1=CC(NC2=CC(F)=C(OC3=C(C(C)=CN4)C4=NC=C3)C(F)=C2)=NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.28 100
Ethanol 40.28 100

Preparing Stock Solutions for TC-S 7001

The following data is based on the product molecular weight 402.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.41 mL 24.83 mL
5 mM 0.50 mL 2.48 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for TC-S 7001

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TC-S 7001

For research use only

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