TC-S 7001

Catalog # Availability Size / Price Qty
4961/1
Cat.No. 4961 - TC-S 7001 | C18H13ClF2N6O | CAS No. 867017-68-3
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Description: Potent and highly selective ROCK inhibitor; orally active
Alternative Names: Azaindole-1

Chemical Name: 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine

Purity: ≥98%

Product Details
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Biological Activity

Potent and highly selective ROCK inhibitor (IC50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively). Exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. Reduces blood pressure in normotensive and hypertensive rats. Orally active.

Technical Data

M.Wt:
402.79
Formula:
C18H13ClF2N6O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
867017-68-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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