Catalog Number: 4961
Alternate Names: Azaindole-1
Chemical Name: 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
Biological Activity
Potent and highly selective ROCK inhibitor (IC50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively). Exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. Reduces blood pressure in normotensive and hypertensive rats. Orally active.
Technical Data
  • M.Wt:
    402.79
  • Formula:
    C18H13ClF2N6O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    867017-68-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase.
    Kast et al.
    Br.J.Pharmacol., 2007;152:1070
  2. Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension.
    Dahal et al.
    Eur.Resp.J., 2010;36:808

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