TC-S 7009

Key Product Details

Product Description

TC-S 7009 is a high affinity and selective HIF-2α inhibitor (K_d = 81 nM). Binds to the HIF-2α PAS-B domain; disrupts HIF-2α-ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2α over HIF-1α. Decreases HIF-2α DNA-binding and attenuates expression of HIF-2α target genes in vitro.

Product Specifications for TC-S 7009

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TC-S 7009

The following data is based on the product molecular weight 308.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.24 mL	16.20 mL	32.40 mL
5 mM	0.65 mL	3.24 mL	6.48 mL
10 mM	0.32 mL	1.62 mL	3.24 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Rogers Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J.Med.Chem. 2013 PMID: 23363003
• Wu Bidirectional modulation of HIF-2 activity through chemical ligands. Nat.Chem.Biol. 2019 PMID: 30804532
• Scheuermann Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat.Chem.Biol. 2013 PMID: 23434853

Product Documents for TC-S 7009