Catalog Number: 3038
Chemical Name: 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol
Biological Activity
Potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.
Technical Data
  • M.Wt:
    412.48
  • Formula:
    C25H24N4O2
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at -80°C
  • CAS No:
    838823-31-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors.
    Teng et al.
    J.Med.Chem., 2007;50:5253
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TCS 2312 include:

2 Citations: Showing 1 - 2
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  1. Checkpoint kinase 1 negatively regulates somatic hypermutation.
    Authors: Frankenberger Et al.
    Nucleic Acids Res 2014;42:3666
  2. Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
    Authors: Davari Et al.
    Cell Cycle 2014;13:3659

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