TCS 2312

Catalog # Availability Size / Price Qty
TCS 2312 | CAS No. 838823-31-7 | Checkpoint Kinase Inhibitors
1 Image
Description: Potent Chk1 inhibitor

Chemical Name: 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol

Purity: ≥97%

Product Details
Citations (2)

Biological Activity

TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.

Technical Data

Soluble to 20 mM in DMSO
Store at -80°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TCS 2312

The citations listed below are publications that use Tocris products. Selected citations for TCS 2312 include:

2 Citations: Showing 1 - 2

  1. Checkpoint kinase 1 negatively regulates somatic hypermutation.
    Authors: Frankenberger Et al.
    Nucleic Acids Res  2014;42:3666
  2. Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
    Authors: Davari Et al.
    Cell Cycle  2014;13:3659


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