Chemical Name: 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol
Biological ActivityTCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors.
Teng et al.
Citations for TCS 2312
The citations listed below are publications that use Tocris products. Selected citations for TCS 2312 include:
2 Citations: Showing 1 - 2
Checkpoint kinase 1 negatively regulates somatic hypermutation.
Authors: Frankenberger Et al.
Nucleic Acids Res 2014;42:3666
Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
Authors: Davari Et al.
Cell Cycle 2014;13:3659
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