Potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki
= 0.38 nM, EC50
= 60 nM). Enhances the cell killing activity of Gemcitabine
(Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro
Soluble to 20 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors.
Teng et al.
The citations listed below are publications that use Tocris products. Selected citations for TCS 2312 include:
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