TCS 2312

  ( 2 citations )    
Product Datasheet
Catalog Number:3038
Chemical Name:4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol
Product Details
Citations (2)
Reviews
Biological Activity
Potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.
Technical Data
  • M.Wt:
    412.48
  • Formula:
    C25H24N4O2
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at -80°C
  • CAS No:
    838823-31-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for TCS 2312 include:

2 Citations: Showing 1 - 2
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  1. Checkpoint kinase 1 negatively regulates somatic hypermutation.
    Authors: Frankenberger Et al.
    Nucleic Acids Res  2014;42:3666
  2. Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
    Authors: Davari Et al.
    Cell Cycle  2014;13:3659

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