Home / Checkpoint Kinase Inhibitors / TCS 2312

TCS 2312

3038 2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3038/1
TCS 2312 | CAS No. 838823-31-7 | Checkpoint Kinase Inhibitors
1 Image
Description: Potent Chk1 inhibitor

Chemical Name: 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.

Technical Data

M.Wt:
412.48
Formula:
C25H24N4O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥97%
Storage:
Store at -80°C
CAS No:
838823-31-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for TCS 2312

The citations listed below are publications that use Tocris products. Selected citations for TCS 2312 include:

2 Citations: Showing 1 - 2

  1. Checkpoint kinase 1 negatively regulates somatic hypermutation.
    Authors: Frankenberger Et al.
    Nucleic Acids Res  2014;42:3666
  2. Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
    Authors: Davari Et al.
    Cell Cycle  2014;13:3659

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TCS 2312

There are currently no reviews for this product. Be the first to review TCS 2312 and earn rewards!

Have you used TCS 2312?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.