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TCS 2312

Catalog #: 3038
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3038/1
TCS 2312 | CAS No. 838823-31-7 | Checkpoint Kinase Inhibitors
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Description: Potent Chk1 inhibitor

Chemical Name: 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.

Technical Data

M.Wt:
412.48
Formula:
C25H24N4O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥97%
Storage:
Store at -80°C
CAS No:
838823-31-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TCS 2312

The citations listed below are publications that use Tocris products. Selected citations for TCS 2312 include:

2 Citations: Showing 1 - 2

  1. Checkpoint kinase 1 negatively regulates somatic hypermutation.
    Authors: Frankenberger Et al.
    Nucleic Acids Res  2014;42:3666
  2. Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
    Authors: Davari Et al.
    Cell Cycle  2014;13:3659

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