Potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki
values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50
= 48 nM). Orally bioavailable.
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All Tocris products are intended for laboratory research use only.
Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-related kinase (ERK) using conformational control.
Aronov et al.