TCS ERK 11e

Catalog # Availability Size / Price Qty
4465/10
Cat.No. 4465 - TCS ERK 11e | C24H20Cl2FN5O2 | CAS No. 896720-20-0
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Description: Potent and selective ERK2 inhibitor
Alternative Names: VX 11e

Chemical Name: 4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.

Technical Data

M.Wt:
500.35
Formula:
C24H20Cl2FN5O2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
896720-20-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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