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TCS ERK 11e

Catalog #: 4465 Datasheet / COA / SDS
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4465/10
TCS ERK 11e | CAS No. 896720-20-0 | ERK Inhibitors
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Description: Potent and selective ERK2 inhibitor
Alternative Names: VX 11e

Chemical Name: 4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

Purity: ≥98%

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Biological Activity

TCS ERK 11e is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.

Technical Data

M.Wt:
500.35
Formula:
C24H20Cl2FN5O2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
896720-20-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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