TCS ERK 11e

Tocris Bioscience | Catalog # 4465

Potent and selective ERK2 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective ERK2 inhibitor

Alternative Names

VX 11e
View all ERK Inhibitors »

Product Description

TCS ERK 11e is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.

Product Specifications for TCS ERK 11e

Molecular Weight

500.35

Formula

C24H20Cl2FN5O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

CAS Number

896720-20-0

PubChem ID

11634725

InChI Key

WUTVMXLIGHTZJC-OAQYLSRUSA-N

SMILES

O=C(N[C@H](CO)C3=CC(Cl)=CC=C3)C1=CC(C2=NC(NC4=CC=C(F)C=C4Cl)=NC=C2C)=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.03 100
Ethanol 12.51 25

Preparing Stock Solutions for TCS ERK 11e

The following data is based on the product molecular weight 500.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.00 mL 9.99 mL 19.99 mL
5 mM 0.40 mL 2.00 mL 4.00 mL
10 mM 0.20 mL 1.00 mL 2.00 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for TCS ERK 11e

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TCS ERK 11e

For research use only

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