TCS OX2 29

Tocris Bioscience | Catalog # 3371

Potent and selective OX2 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective OX2 antagonist
View all OX2 Receptor Antagonists »

Product Description

TCS OX2 29 is a potent and selective OX2 receptor antagonist (IC50 = 40 nM). Displays >250-fold selectivity for OX2 over OX1 and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.

Product Specifications for TCS OX2 29

Molecular Weight

433.97

Formula

C23H31N3O3.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride

CAS Number

1610882-30-8

PubChem ID

53302033

InChI Key

NHKNHFJTMINMBP-ZMBIFBSDSA-N

SMILES

C[C@@](C)(C)[C@H](NCC3=CC=NC=C3)C(N(C2)CCC1=C2C=C(OC)C(OC)=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 43.4 100
DMSO 10.85 25

Preparing Stock Solutions for TCS OX2 29

The following data is based on the product molecular weight 433.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.30 mL 11.52 mL 23.04 mL
5 mM 0.46 mL 2.30 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.30 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 63 publications citing the usage of this product.

Product Documents for TCS OX2 29

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TCS OX2 29

For research use only

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