TCS OX2 29

Catalog # Availability Size / Price Qty

Save Up to 40% on RUO Reagents with BIOSPRING24 (See Details)

TCS OX2 29 | CAS No. 1610882-30-8 | OX2 Receptor Antagonists
1 Image
Description: Potent and selective OX2 antagonist

Chemical Name: (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride

Purity: ≥98%

Product Details
Citations (9)
Supplemental Products

Biological Activity

TCS OX2 29 is a potent and selective OX2 receptor antagonist (IC50 = 40 nM). Displays >250-fold selectivity for OX2 over OX1 and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.

Technical Data

Soluble to 100 mM in water and to 25 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for TCS OX2 29

The citations listed below are publications that use Tocris products. Selected citations for TCS OX2 29 include:

9 Citations: Showing 1 - 9

  1. Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian mice
    Authors: Bian Et al.
    Neurosci Lett  2021;765:136291
  2. The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats.
    Authors: Asadi
    BMC Neurosci  2018;19(1):49
  3. Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats.
    Authors: Zhou Et al.
    Neuropharmacology  2015;99:481
  4. Both Ox1R and Ox2R orexin receptors contribute to the cardiorespiratory response evoked from the perifornical hypothalamus.
    Authors: Beig Et al.
    Clin.Exp.Pharmacol.Physiol.  2015;42:1059
  5. Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals.
    Authors: Shu Et al.
    PLoS One  2014;9:e95259
  6. A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior.
    Authors: Plaza-Zabala Et al.
    J Mol Neurosci  2013;38:1724
  7. Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats.
    Authors: Brown Et al.
    Int.J.Neuropsychopharmacol.  2013;16:2067
  8. Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures.
    Authors: Urbańska Et al.
    PLoS One  2012;46:42561
  9. Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors.
    Authors: Huang Et al.
    J Pharmacol Exp Ther  2010;334:522


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TCS OX2 29

There are currently no reviews for this product. Be the first to review TCS OX2 29 and earn rewards!

Have you used TCS OX2 29?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.