Potent and selective OX2
receptor antagonist (IC50
= 40 nM). Displays >250-fold selectivity for OX2
and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP3
accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist.
Hirose et al.
Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.
Mould et al.
The citations listed below are publications that use Tocris products. Selected citations for TCS OX2 29 include:
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