TDZD 8

Tocris Bioscience | Catalog # 6092

Selective non-ATP competitive inhibitor of GSK 3β
Tocris Bioscience

Key Product Details

Description

Selective non-ATP competitive inhibitor of GSK 3β

Alternative Names

NP 01139
View all GSK-3 Inhibitors »

Product Description

TDZD 8 is a selective non-ATP competitive inhibitor of GSK 3β (IC50 = 2 μM); thiadiazolidinone deriviative. Does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. Reduces severity of L-dopa-induced dyskinesia in a Parkinson's disease in vivo model.

Product Specifications for TDZD 8

Molecular Weight

222.26

Formula

C10H10N2O2S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione

CAS Number

327036-89-5

PubChem ID

4124851

InChI Key

JDSJDASOXWCHPN-UHFFFAOYSA-N

SMILES

CN1SC(N(C1=O)CC2=CC=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.23 100
Ethanol 22.23 100

Preparing Stock Solutions for TDZD 8

The following data is based on the product molecular weight 222.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.50 mL 22.50 mL 44.99 mL
5 mM 0.90 mL 4.50 mL 9.00 mL
10 mM 0.45 mL 2.25 mL 4.50 mL
50 mM 0.09 mL 0.45 mL 0.90 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for TDZD 8

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TDZD 8

For research use only

Related Research Areas

Notch Pathway

Customer Reviews for TDZD 8 (1)

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  • Great GSK3 inhibitor
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: Brain
    Verified Customer | Posted 11/25/2021
    We treated mice with TDZD-8 at 30 mg/kg, i.p. for 1 h
    I have used TDZD to inhibit GSK3 in the brain of mice. After the treatment, we investigated if the NCS-1 gene would increase its expression as we have hypothesised the GSK3 protein impairs NCS-1 gene expression. We found that this happened, but only in the pre frontal cortex (PFC) as showed by the figure.
    TDZD 8 6092

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