Catalog Number: 5139
Chemical Name: 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid
Biological Activity
Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.
Technical Data
  • M.Wt:
    514.62
  • Formula:
    C33H30N4O2
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    144701-48-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. An adipose tissue-independent insulin-sensitizing action of telmisartan: a study in lipodystrophic mice.
    Rong et al.
    J.Pharmacol.Exp.Ther., 2009;331:1096
  2. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity.
    Benson et al.
    Hypertension, 2004;43:993
  3. 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships.
    Ries et al.
    J.Med.Chem., 1993;36:4040
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Telmisartan include:

1 Citations: Showing 1 - 1

  1. Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats.
    Authors: Lin Et al.
    Psychopharmacology (Berl) 2015;9:4709

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