High affinity and selective EP2
receptor antagonist (KB
values are 2.4 and 34.5 nM for EP2
receptors respectively). Exhibits >500-fold selectivity for EP2
over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
EP2 receptor signaling pathways regulate classical activation of microglia.
Quan et al.
Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.
Jiang and Dingledine
The citations listed below are publications that use Tocris products. Selected citations for TG 4-155 include:
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