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TG 4-155

Catalog #: 5052
2 Citations Datasheet / COA / SDS
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5052/10
5052/50
TG 4-155 | CAS No. 1164462-05-8 | Prostanoid Receptor Antagonists
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Description: High affinity and selective EP2 receptor antagonist

Chemical Name: (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

TG 4-155 is a high affinity and selective EP2 receptor antagonist (KB values are 2.4 and 34.5 nM for EP2 and DP1 receptors respectively). Exhibits >500-fold selectivity for EP2 over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.

Technical Data

M.Wt:
394.46
Formula:
C23H26N2O4
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1164462-05-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TG 4-155

The citations listed below are publications that use Tocris products. Selected citations for TG 4-155 include:

2 Citations: Showing 1 - 2

  1. GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons.
    Authors: Cuesto Et al.
    PLoS One  2015;10:e0118475
  2. GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons.
    Authors: Cuesto Et al.
    PLoS One  2015;10:e0118475

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VersaClone cDNA Plasmids

Human PTGER2 (NP_000947) VersaClone cDNA

RDC0174

Mouse PTGER2 (NP_032990) VersaClone cDNA

RDC0385

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