Catalog Number: 5052
Chemical Name: (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
Biological Activity
High affinity and selective EP2 receptor antagonist (KB values are 2.4 and 34.5 nM for EP2 and DP1 receptors respectively). Exhibits >500-fold selectivity for EP2 over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.
Technical Data
  • M.Wt:
    394.46
  • Formula:
    C23H26N2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1164462-05-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. EP2 receptor signaling pathways regulate classical activation of microglia.
    Quan et al.
    J.Biol.Chem., 2013;288:9293
  2. Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.
    Jiang and Dingledine
    J.Pharmacol.Exp.Ther., 2013;344:360
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TG 4-155 include:

1 Citations: Showing 1 - 1

  1. GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons.
    Authors: Cuesto Et al.
    PLoS One 2015;10:e0118475

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