Potent and selective PI 3-kinase β
values are 0.007, 0.1, 3.5 and 5 μ
M for the β
isoforms, respectively). Shows >1,000-fold selectively for PI 3-kinase β
over a range of other kinases. Inhibits thrombus formation in animal models.
Soluble to 50 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
PI 3-kinase p110β: a new target for antithrombotic therapy.
Jackson et al.
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Condliffe et al.