TGX 221

Key Product Details

Product Description

TGX 221 is a potent and selective PI 3-kinase β inhibitor (IC₅₀ values are 0.007, 0.1, 3.5 and 5 μM for the β, δ, γ and α isoforms, respectively). Shows >1,000-fold selectively for PI 3-kinase β over a range of other kinases. Inhibits thrombus formation in animal models.

Product Specifications for TGX 221

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TGX 221

The following data is based on the product molecular weight 364.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.49 mL	27.44 mL	54.88 mL
2.5 mM	1.10 mL	5.49 mL	10.98 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
25 mM	0.11 mL	0.55 mL	1.10 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Jackson PI 3-kinase p110β: a new target for antithrombotic therapy. Nat.Med. 2005 PMID: 15834429
• Condliffe Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 2005 PMID: 15878979

Product Documents for TGX 221